Protective effect of methanolic extract of Trianthema portulacastrum in atherosclerotic diet induced renal and hepatic changes in rats

By A. Shyam Sunder, A. Rama Narsimha Reddy, Y. Rajeshwar, G. Kiran, D. Krishna Prasad, B. Baburao, S. Thirumurugu and A. Karthik

Abstract

The aim of the present study was to investigate the protective effect of Methanolic Extract of Trianthema portulacastrum plant (METP) in atherosclerotic diet induced renal and hepatic changes in rats. Atherosclerotic diet or CCT diet was successfully induces atherosclerosis/hyperlipidemia in rats by elevating the serum lipid levels and also produced glomerulosclerosis / nephropathy and early fatty changes in the liver cells. The treatment with METP extract at doses of 100 & 200 mg/kg, b.w produced a marked reduction in these elevated serum lipid levels and protected against the glomerulosclerosis or fatty changes in the hepatocytes induced by the atherosclerotic diet. The protective role of METP was confirmed by the significant reduction in the elevated serum LDH, AST, ALT, ALP, bilirubin and creatinine levels when compared with CCT diet fed control group and also by the histopathological evaluations of glomeruli, renal tubules and liver sections.

 

Key Words : Trianthema portulacastrum; atherosclerotic diet; CCT diet; glomerulosclerosis; protective effect; AST; ALT.

 

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