Hepatoprotective effects of 50% ethanolic extract of Mimosa pudica against CCl4 induced hepatotoxicity in rats 

By Senthil Kumar K., Senthil Kumar K. L. 


The hepatoprotective effect of 50% ethanolic extract of Mimosa pudica L (Fabaceae) by carbon tetrachloride (CCl4) induced liver damage in rats. The 50% ethanolic extract of M. pudica was studied for their hepatoprotective effects on CCl4 induced liver damage on Wistar albino rats. The degree of protection was measured by physical changes (liver weight), biochemical (SGPT, SGOT, ALP, total bilirubin, albumin and decreases in total protein). Pretreatment with extract significantly prevented the physical, biochemical changes induced by CCl4 in the liver. The effects of extract of M. pudica were comparable to that of standard drug, silymarin. These results indicate that the M. pudica could be useful in preventing chemically induced acute liver injury. From this study, it can be concluded that the 50% ethanol extracts of M. pudica possesses significant hepatoprotective activity. 


Key Words : Carbon tetrachloride, hepatoprotective, M. pudica.


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