By Mohd Rashid, Asif Husain, Ravinesh Mishra, Bahar Ahmad
Some new various aromatic aldehyde derivatives of 7-chloro-5-phenyl-1,3-dihydro-1H,1,4-benzodiazepine-2-one were synthesized and evaluated for their anti-anxiety activity by using elevated plus-maze method. The activity of all synthesized compounds were compared with diazepam which was used as standard drug. Compounds 4a, 4b, 4e, 4j and 4k were found to have significant activiity .
Key Words : 1,4-Benzodiazepin-2-one, diazepam, elevated plus-maze apparatus, anti-anxiety activity.
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