Synthesis and anti-anxiety activity of some 7-chloro-5-phenyl-1,3-dihydro-1H,3H-1,4-benzodiazepine-2-one derivatives in mice 

By Mohd Rashid, Asif Husain, Ravinesh Mishra, Bahar Ahmad 


Some new various aromatic aldehyde derivatives of 7-chloro-5-phenyl-1,3-dihydro-1H,1,4-benzodiazepine-2-one were synthesized and evaluated for their anti-anxiety activity by using  elevated plus-maze method. The activity of all synthesized compounds were compared with diazepam which was used as standard drug. Compounds  4a, 4b, 4e, 4j and 4k were found to have significant activiity . 


Key Words : 1,4-Benzodiazepin-2-one,  diazepam, elevated plus-maze  apparatus, anti-anxiety activity.


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