Synthesis and evaluation of anti-microbial and analgesic activity of some (4Z)-3-methyl-1-[(2-oxo-2H-chromen-4-yl)carbonyl]-1H-pyrazole-4,5-dione4-[(4-substitutedphenyl) hydrazone] 

By K. K. Sivakumar, A. Rajasekaran, I. Ponnilavarasan, A. Somasundaram, R. Sivasakthi, S. Kamalaveni 


A series of (4Z)-3-methyl-1-[(2-oxo-2H-chromen-4-yl) carbonyl]-1H-pyrazole-4,5-dione 4-[(4-substitutedphenyl)hydrazone] (5a-i) have been synthesized. All the synthesized compounds were characterized on the basis of elemental analysis and spectral data (IR, 1HNMR). The titled compounds were screened for their anti-inflammatory and analgesic activity. Among the synthesized compounds, compound 5a, 5c, 5g and 5h exhibited significant anti-microbial activity and compound 5a, 5b, 5d, 5h and 5i exhibited significant analgesic activity compared with the standard drug (indomethacin 5mg/kg) at the dose level of 50mg/kg on oral administration. 


Key Words : Microbial, pain, coumarin, pyrazolin-5-one


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