New Strategy for Solubilization of poorly soluble drug- SEDDS
By Mishra Nidhi, Srivastava Shikha
Self-emulsifying drug delivery systems (SEDDSs) have gained exposure for their ability to increase solubility and bioavailability of poorly soluble drugs. Self-emulsifying drug delivery systems (SEDDS) are mixtures of oils, surfactants, and cosurfactants, which are emulsified in aqueous media under conditions of gentle stirring and digestive motility that would be encountered in the gastrointestinal tract. We found that SEDDS could efficiently improve oral absorption of the sparingly soluble drugs by rapid self-emulsification and subsequently dispersion in the absorption sites.
Key Words : SEDDS, poorly-soluble,self emulsifying, co-solvents, SMEDDS
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