Taste abatement of Metoclopramide Hydrochloride using ion exchange resins


By Mahore, J.G., Wadher, K.J., Umekar, M.J.


The purpose of present research work was mask the bitter taste of Metoclopramide HCl using weak cation ion exchange resins (Indion 234) that contained crosslinked polyacrylic backbone. The drug resin complexes (DRC) were prepared by batch process by taking drug: resin ratios 1:1, 1:2 and 1:3. The optimum drug: resin ratio and the time required for maximum complexation was determined. The drug resinates were evaluated for the drug content, taste, micromeritic properties, drug release and infrared studies. The effect of batch process, complexation time, activation of ion exchange resin, temperature, complexation mode and pH on Metoclopramide HCl loading with Indion-234 were also carried out. IR analysis, assay content and decomplexation studies give evidence of complex formation. The taste evaluation depicted the successful taste masking of Metoclopramide HCl with drug resin complexes


Key Words : Metoclopramide Hydrochloride, Indion 234, Drug resin complex

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