Antinociceptive and anti-inflammatory activities of Tagetes erectus flowers in animal models
By Guno Sindhu Chakraborthy
In the present study potential of chloroform extract of Tagetes Erectus (Family- Compositae) flowers on antinociceptive, behavioral study and anti-inflammatory effects using various animal models. The dried, powdered flowers of Tagetes Erectus were extracted successively with petroleum ether (60-80° C) and chloroform in soxhlet apparatus. The chloroform extract yield (20.6 % w/w with respect to dry powdered plant material) was selected for all experimental procedure. Two models were employed to investigate the effects on nociception; tail immersion and hot plate method in Swiss albino mice and anti-inflammatory effect were investigated by employing the carrageenan induced paw edema test in adult Wistar albino rats. Behavioral study was investigated by elevated plus maze method in Swiss albino mice. Results were revealed that the TECE was found significant antinociceptive effect (p< 0.001) at dose levels of 100, 200 and 400 mg/kg, orally in mice and produced a remarkable anti-inflammatory effect (p<0.001) at the same dose levels used in rats. Behavioral study of the TECE has no significant effect when used orally. Thus from the above findings it can be concluded that, TECE possessed remarkable antinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.
Key Words : Tagetes Erectus, Chloroform extract, inflammation, antinociceptive, paw edema.
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