The study of the effects of surfactants on ethylcellulose microspheres containing salbutamol sulphate
By Lalduhsanga Pachuau, Sushanta Sarkar, Bhaskar Mazumder
Microspheres containing Salbutamol sulphate was prepared by emulsion solvent evaporation technique using two types of surfactants, Tween 80 (polysorbate 80) and Span 80 (sorbitan monooleate 80). Infrared Spectroscopy, Differential Scanning Colorimetry and X-Ray Diffraction Spectroscopy studies were carried out to study whether the surfactants have any impact on the physicochemical properties of the microspheres. Scanning Electron Microscopy was done to study the surface topography of the microspheres. When Span 80 was used, the microspheres were smaller in size as compared to those obtained using Tween 80 while there was a higher release rate when Tween 80 was used.
Key Words : Tween 80, Span 80, Microspheres, Salbutamol sulphate, emulsion solvent-evaporation technique.
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