Dissolution profile of ketoprofen cyclodextrin complex

By Kushwaha Swatantra S. K., Rai A. K., Maurya Neelottama, Singh Satyawan

 

Abstract

Ketoprofen, 3-benzoyl-a-methylbenzeneacetic acid, is one type of non-steroidal anti- nflammatory drug and a weak acid poorly soluble in water. The effect of complexation Ketoprofen, a poorly water soluble non-steroidal anti-inflammatory drug (NSAID) with Cyclodextrins showed significant increase in dissolution profile with comparison a pure drug. Inclusion complexes were prepared by various methodologies i.e. co-precipitation, kneading etc, in molar ratio 1:1, 1:2, 1:3.

 

Key Words : Ketoprofen, ß-Cyclodextrins, HP-ß-Cyclodextrins

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