Antidiabetic and antioxidant activity of Lmonia acidissima linn. in alloxan induced rats 

By K. Ilango, V. Chitra 



 The present work is carried out to study the effect ofLimonia acidissima.Linn (Rutaceae) on blood glucose levels and antioxidant enzymes levels in Alloxan induced diabetic rats. Alloxan (120 mg/kg, i.p)     induced diabetic rats were treated with Limonia acidissima methanolic extract at a dose levels of 200 and 400 mg/kg for 21 days. Glucose level was measured in blood serum and antioxidant enzymes levels viz. Superoxide dismutase (SOD), Catalase (CAT) and Lipid Per oxidation (LPO) were measured in pancreatic homogenate, methanolic extract of fruit pulp ofLimonia acidissima.Linn significantly (P<0.01) lowered the Alloxan induced hyperglycemia. It also produced a significant (P<0.01) decrease in peroxidation products viz. MDA in blood serum. The activity of antioxidant enzymes such as SOD, CAT was found to be higher in the blood serum of diabetic animals treated with the Limonia acidissima extract. This confirms the antihyperglycemic and antioxidant activities ofLimonia acidissima in Alloxan induced diabetic rats.

Key Words : Limonia acidissima, anti diabetic activity, alloxan, antioxidant enzymes, histopathology.

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