Continuous sleep deprivation for 5 days produces loss of memory in mice and may be a cause of Alzheimer’s disease
By Habibur Rahman, P. Muralidharan, D. Sivaraman, Dipankar Saha
Introduction: Sleep disturbances and dementia increases with advancing age and about 45% of Alzheimer patients have disruptions in their sleep and sundowning agitation. Clinical evidence showed that people who suffer from chronic insomnia are about 11 times more likely to develop Alzheimer in latter life. Methods: The present study was undertaken to study the effect of Sleep deprivation in learning and memory and correlates with the cause of Alzheimer’s disease. In this method, mice were deprived from sleep for 5 days by using multiple platform method and Behavioral changes were evaluated using passive avoidance, Y-maze, Elevated plus maze and Morris water-maze tests. Results: Sleep deprivation in mice showed significant decrease in learning and memory as behavioral changes studied from passive avoidance, Y-maze, Elevated plus maze and Morris water-maze tests. Conclusion: This finding suggests that Chronic Sleep Deprivation can be cause of Alzheimer’s disease in their later life.
Keywords: Sleep deprivation, Morris water-maze test, Y-maze, Alzheimer’s disease
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