Interleukin (IL)-10 and tumor necrosis factor-alpha (TNF-a) profiles of Nigerians with Trypanosoma brucei gambiense infection

By Isaac, C., Nmorsi, O.P.G., Igbinosa, I.B., Umukoro, D.O., Imarenezor, E.P.K, Ihimire, I.G. and Akinboyeku, A.W.

Abstract

We evaluated the profile of interleukin (IL)-10 and tumor necrosis factor-alpha (TNF-a) of 35 volunteers infected with Trypanosoma brucei gambiense in three human African trypanosomiasis (HAT) endemic communities in Abraka, Nigeria. Serum IL-10 levels were significantly higher in strongly positives than control subjects (P<0.001).The difference in serum IL-10 concentrations between early and late stages of infection was statistically significant (P<0.001). Significant elevation of CSF IL-10 concentrations was observed for HAT late stage (P<0.001). The level of TNF-a for weakly positive, moderately positive and strongly positive were significantly elevated when compared with the control subjects at ?2 =6.37, P>0.01; ?2 =22.79, P<0.001, ?2=35.57, P<0.001, respectively. The mean difference in serum TNF-a concentrations between early and late stages of infection was statistically significant (P<0.0001) but not significant for CSF TNF-a levels (P>0.05). We therefore suggest that the elevated levels of IL-10 and TNF-a may implicate these cytokines as mediators of host response to HAT infection in our locality.

 

Key Words : Interleukin -10; Tumor necrosis factor-alpha (TNF-a); Trypanosoma brucei gambiense; Human African Trypanosomiasis (HAT), Nigeria.

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