Evaluation of Delonix regia Linn. flowers for antiarthritic and antioxidant activity in female wistar rats

By V. Chitra, K. Ilango, M. G. Rajanandh and D. Soni

Abstract

The alcoholic extract of the flowers of Delonix regia Linn. (Family: Caesalpinaceae) was evaluated for antiarthritic activity in adult female Wistar rats. Two doses of 200mg/kg and 400mg/kg of alcoholic extract of Delonix regia were administered intraperitoneally to the Freund`s incomplete adjuvant induced arthritis in rats for 28 days. During the experimental period, paw edema volume (primary lesion) was observed. Liver homogenate was utilized for the assessment of oxidative stress. Our results suggest that both the doses of alcoholic extract of Delonix regia significantly reduced the paw edema volume as compared to diseased control animals. Treatment with Delonix regia also showed significant increase in antioxidant enzyme levels like Catalase (CAT), Glutathione peroxidase (GPx), Glutathione –S- Transferase (GST), reduced glutathione (GSH), Vit – C with decreased protein level and the values were almost analogous to that of normal values.

 

Key Words : Arthritis, Antiarthritic activity, Antioxidant enzyme levels, Delonix regia, Freund`s incomplete adjuvant.

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