Current biological and synthetic profile of triazoles: A review 

By Priyanka P. Gadhave, Nachiket S. Dighe, Shashikant R. Pattan, Pravin Deotarse, Deepak S. Musmade, R. V. Shete 

Abstract

Triazole is a five membered heterocyclic system consisting of two carbon atoms and three nitrogen atoms shows wide range of biological activities. Triazoles can be synthesized using Einhorn-Brunner reaction or the Pellizzari reaction from acyl hydrazides. Triazoles posses wide spectrum of biological activities like including antibacterial, antifungal, antiviral, anti-inflammatory, anticonvulsant, antidepressant, antihypertensive, analgesic, and hypoglycemic properties. The present reviews attempted to gather the various developments in synthesis and biological activities of triazole derivatives. 

 

Key Words : 1, 2, 4-Triazole, Pharmacological activity, SAR, Total synthesis. 

 

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