Hepatoprotective studies on aerial parts of Moringa oleifera Lam. on carbon tetrachloride induced liver cell damage in albino rats

 

By Prashant Kumar, Kuldeep Singh, Amit Kumar

Abstract

The extracts from leaves, flower and isolated fraction of Moringa oleifera Lam. were evaluated for hepatoprotective activity in rats with liver damage induced by Carbon tetra chloride. The extract at an oral dose of 250 mg/kg exhibited a significant protective effect by lowering the serum levels of bilirubin, glutamate pyruvate transferase (SGPT), glutamate oxaloacetate transferase (SGOT), alkaline transferase and lysosomal enzymes. These biochemical observations were supplemented by histopathological examination of liver sections. The activity of extract was also comparable to that of silymarin, a known hepatoprotective agent.

 

Key Words : Moringa oleifera, SGPT, SGOT, ALP, Bilirubin, Carbon tetrachloride, Silymarin.  

 

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