Phytochemical and anti-ulcer investigations of 95% ethanolic-benzene-chloroform leaf extract of Hibiscus tiliaceus Linn. in albino rat model 

By Mukesh Chandra Sharma, Smita Sharma, Dharm Veer Kohli


Abstract

The present study was undertaken to evaluate the fresh leaf extract of Hibiscus tiliaceus Linn. (Malvaceae) for its anti-ulcer activity in pyloric ligation (PL induced gastric ulcer models in Albino rats. Methanol, petroleum ether and chloroform extract of Hibiscus tiliaceus Linn. (Malvaceae) was explored for antiulcer and gastroprotective activity using acute gastric lesion induced by cold restraint stress and pylorus ligation in rats. The anti-ulcer activity of extract of the leaves Hibiscus tiliaceus was evaluated by using models of acute gastric lesions induced by cold restrain stress and pylorus ligation in rats. Animals pretreated with doses of 150 mg/kg and 250 mg/kg of Methanol, petroleum ether and chloroform extract showed significant reduction in lesion index, total affected area and percentage of lesion in comparison with control group in the cold restraint stress-induced ulcer and pylorus ligation models.  

 

Key Words : Hibiscus tiliaceus, Formulation, Phytochemical, Pylorus ligation

 

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