Overt Diabetic Complications in Obese Type 2 Diabetes Mellitus Patients from North India

 

By Madhukar Saxena, CG Agrawal, Sunaina Gautam, Hemant K. Bid, Monisha Banerjee

 

Abstract

Heredity is a major determining factor in the development of diabetes and obesity. Obesity decreases the number of insulin receptors in the insulin target cells throughout the body; thus reducing the metabolic effect of insulin. Our objective was to evaluate the complications in Type 2 diabetic (T2DM) patients from North India. The study was conducted on 300 patients with a mean age of 48.61 ± 9.96 (range 22-77 years). Lipid profile was estimated by using Ecoline Kits. Clinical parameters were analyzed and recorded for association. Out of the 300 diabetic patients (171 males and 129 females); 241 (127 males and 114 females) manifested one or more diabetic complications such as retinopathy (Rt); nephropathy (Np) and neuropathy (Nu). Out of these 241; 109 were obese and 132 were non-obese. Obese diabetics when compared to non obese diabetic patients showed statistically significant increase in the levels of serum total cholesterol (TC) (p = 0.030); serum Low Density Lipoprotein (LDL)-cholesterol (p = 0.049); Very Low Density Lipoprotein (VLDL)-cholesterol (p = 0.008); serum creatinine (p = 0.047) and decreasing serum High Density Lipoprotein (HDL)-cholesterol (p = 0.000). Single complications viz Rt; Np and Nu were manifested by 62.39; 10.19 and 16.51% obese T2DM patients respectively while 1.83% had Rt+Np; 7.34% had Rt+Nu and 1.83% showed all the three complications. The difference between obese and non obese subjects was highly significant (p=0.000). Our study also indicated that the prevalence of complications was 2.7-3.7 times high in obese diabetics in the North Indian population and showed significant association with lipid profiles.

 

Key Words : Type 2 Diabetes Mellitus; Obesity; Diabetic Complications; Clinical Parameters

 

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