Evaluation of Anti-asthmatic Activity of Aqueous Extract of Achillea mellifolium Linn Flowers

By Raju.D, Chitra.V, Sri Hari Das.K, Silambu Janiki.P, Shankari.M

Abstract

The present study was designed to evaluate the anti-asthmatic activity of aqueous extract of flowers of Achillea mellifolium Linn. belonging to the family Asteracae (Compositae). The anti-asthmatic activity of the extract 5, 10, 15, 20, 25, 30mg/ml was evaluated in guinea pig ileum, guinea pig trachea chain, rat ileum, rat fundus isolated preparations by using standard drugs Histamine, Acetyl Choline & 5- HT respectively. The extract significantly inhibited all the response produced by the inflammatory mediators used and maximum significant anti-asthmatic activity was observed at the doses of 25, 30 mg/ml.

 

Key Words : Achillea mellifolium, anti-asthmatic activity, acetyl choline, histamine, 5-HT

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