Formulation and evaluation of Cefadroxil dispersible tablets
By N. Damodharan, M. Manimaran, P. Suresh Kumar
Cefadroxil dispersible tablets were fabricated with crospovidone, sodium starch glycolate and croscarmellose sodium as superdisintegrants with cefadroxil as model drug. Various pre-compressional parameters like angle of repose, compressibility index and hausner’s ratio and post compressional parameters like weight variation, thickness, hardness, friability, disintegration time, dispersion time, wetting time, assay and drug release were studied. Formulations containing croscarmellose sodium and sodium starch glycolate showed decrease in angle of repose with increase in concentration. Angle of repose increased with increase in concentration of crospovidone. Formulations prepared with direct compression method showed good release properties when compared with wet granulation method. The wetting time decreased with increase in the concentration of crospovidone, while the wetting time of the tablets containing croscarmellose sodium and sodium starch glycolate did not change with increase in concentration. In dispersion study, the formulations consists of crospovodone have showed better results compared to other formulations. In disintegration study, formulations consists of crospovidone have showed better results compared to other formulations.
Key Words : Cefadroxil, wet granulation, direct compression, dispersible tablets
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